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Regenerative Collagen Membranes

Our regenerative biologic products are indicated for use in a variety of bone repair procedures such as augmentation or reconstructive treatment of the alveolar ridge and filling of periodontal defects. The regenerative collagen membranes are intended for Guided Tissue Regeneration and Guided Bone Regeneration and are suitable for use in conjunction with our bone graft products for bone fill in defects created after root resection, tooth extraction, periodontal disease and elevation of the maxillary sinus floor.

GEM® Dental Membranes

Our COLLAGEN MEMBRANES GEM® Adapt and GEM® EXT are intended for use in oral surgical procedures as a resorbable material for use in augmentation around implants placed in immediate extraction sockets or delayed extraction sockets, localized ridge augmentation for later implantation, alveolar ridge reconstruction for prosthetic treatment, filling of bone defects, guided bone regeneration in dehiscence defects and guided tissue regeneration procedures in periodontal defects.

GEM® CAP is intended for use in oral surgical procedures as a resorbable material for use in extraction sockets and small bone defects. GEM dental membranes provide a portfolio of collagen based resorbable dental membranes that meet the needs of various dental indications.

Three key design attributes include:

  • Handling characteristics: Conformability vs. Stiffness
  • Suture pullout strength
  • Resorption time

Consideration of these attributes allows the clinician to select the most ideal membrane for the type of procedure she/he is performing.

Membranes Collagen Source Conformability Suture Pullout Strength Resorption Time
GEM® ADAPT RCM Porcine peritoneum High (very adaptable) High 0.83kg Short: 3-4 months
GEM® EXT RCM Porcine dermis Moderate Moderate 0.46kg Moderate: 6-9 months
GEM® CAP Porcine dermis Low (highly space maintaining) Moderate 0.51kg Extended: 9-12 months

Membrane Features

  • Highly purified collagen derived from porcine tissue
  • Highly biocompatible
  • Structural integrity for easy handling and suturing
  • Permeable to macromolecules and nutrients while creating an effective barrier to epithelial cells
  • Conformable and repositionable for precise adjustment and placement
  • Programmed resorption time to accommodate various applications
  • Terminally sterilized and ready for use following brief hydration

GEM ADAPT RCM

Scanning Electron Microscopy

Figure 1. SEM micrograph of GEM® Adapt RCM (cross-section) at 50x magnification2).

Figure 2. SEM micrograph of the Bio-Gide® (cross-section) at 50x magnification2.

Table I. Results of In Vitro Characterization Studies

Performance/Characterization Parameter GEM® ADAPT Bio-Gide®
Hydroxyproline Content (Weight %)1, 2 11.7 ± 1.1% 11.8 ± 0.8%
Suture Pull-out Strength2 953 ± 110g 330 ± 120g
Conformability2 Highly Highly
Hydrothermal Shrinkage Temperature (TS)2, 3 56 ± 1°C 45 ± 3°C

Figure 3. In vitro degradation of collagen from membranes by collagenase digestion. Digestion times: 8, 16, 24 and 48 hours.

Figure 4. Plot of % implant remaining and % new collagen for GEM® ADAPT.

Figure 5. Plot of % implant remaining and % new collagen for BioGide.

References

  1. Nimni, M.E. Semin. Arthritis Rheum. 8(1), 1983.
  2. Data on file with manufacturer.
  3. Yuen et al. Trans. 6th World Biomaterials Congress. p.1288, 2000.

GEM Adapt RCM

Regenerative Collagen Membrane

3-4 MONTH RESORPTION TIME

GEM® Adapt regenerative collagen dental membrane is a strong, yet flexible collagen barrier membrane manufactured from purified porcine peritoneum tissue. The combination of strength and flexibility is optimized in this membrane, while maintaining excellent handling characteristics. The membrane can be repositioned if necessary and does not stick to instruments during placement.

It is intended for use in oral surgical procedures as a resorbable membrane material for guided bone regeneration procedures, augmentation around implants placed in immediate extraction or delayed extraction sockets, alveolar ridge reconstruction, filling of infrabony periodontal defects and defects after root resection, and guided tissue regeneration procedures in periodontal defects.

  • Highly purified intact collagen
  • Highly biocompatible
  • High mechanical strength
  • Resorbs in 3-4 months
  • Soft and adaptable
  • Does not stick to itself or to instruments
  • Repositionable for precise placement

15mm x 20mm | Product Code: LBADAPT1520
20mm x 30mm | Product Code: LBADAPT2030
30mm x 40mm | Product Code: LBADAPT3040

GEM Ext RCM

Regenerative Collagen Membrane

6-9 MONTH RESORPTION TIME

GEM® EXT porcine collagen membrane has the enhanced characteristics to provide periodontal and dental surgeons with an excellent balance of properties to effectively address a host of clinical indications and surgical procedures where space maintenance is critical.

GEM® EXT is manufactured to strike the right balance among critical product characteristics to deliver predictable results and easily support the clinician’s preferred techniques.

GEM® EXT has been designed to simultaneously achieve moderate adaptability, strength, structural integrity, in vivo stability and provide the clinician the ability to reposition the membrane for ideal placement prior to closure. It has sufficient memory to maintain space for bone and tissue ingrowth. The programmed resorption time of 6 to 9 months, allows for sufficient time to allow for ingrowth and remodeling of new bone.

  • Highly purified intact collagen
  • Highly biocompatible
  • High mechanical strength
  • Resorbs in 6-9 months
  • Space maintaining
  • Balanced characteristics of handling and strength with longer resorption time

15mm x 20mm | Product Code: LBEXT1520
20mm x 30mm | Product Code: LBEXT2030
30mm x 40mm | Product Code: LBEXT3040

GEM Cap RCM

Regenerative Collagen Membrane

9-12 MONTH RESORPTION TIME

GEM® Cap is specifically designed to meet the needs for socket ridge preservation procedures. It has a slight curve when hydrated to facilitate placement. It is resorbable in 9-12 months for extended stability. The size, shape, strength, in vivo stability, and stiffness are particularly useful for guided bone regeneration in socket preservation.

  • Highly purified intact collagen
  • Highly biocompatible
  • Curves when hydrated to facilitate placement
  • Shape and curvature ideal for socket ridge preservation
  • Resorbable in 9-12 months

12mm x 16mm | Product Code: LBCAP1216